Oligo Synthesis : CEPs
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8-Aza-7-deaza-A-CE Phosphoramidite
8-Aza-7-deaza-A-CE Phosphoramidite
Glen Research
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-3083-02 | 8-Aza-7-deaza-A-CE Phosphoramidite | 0.25g | £1,200.00£1,140.00Offer until : 31-Dec-2020Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3083-90 | 8-Aza-7-deaza-A-CE Phosphoramidite | 100µmoles | £480.00£456.00Offer until : 31-Dec-2020Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3083-95 | 8-Aza-7-deaza-A-CE Phosphoramidite | 50µmoles | £240.00£228.00Offer until : 31-Dec-2020Offer Code : GLEN5View Offer | Quantity | Add to Order |
Related products
8-Aza-7-deaza-A-CE Phosphoramidite
8-Aza-7-deaza-A-CE Phosphoramidite
Glen Research
| 8-Aza-7-deaza-A-CE Phosphoramidite |
Catalog Number: 10-3083-xx
Description: 8-Aza-7-deaza-A-CE Phosphoramidite
| 5"-Dimethoxytrityl-N6-dimethylaminomethylidene-8-aza-7-deaza-Adenosine,2"-O-TBDMS-3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite | ||
| Formula: C49H67N8O7PSi | M.W.: 939.16 | F.W.: 329.21 |
Diluent: Anhydrous Acetonitrile |
| Coupling: 12 minute coupling time recommended. |
| Deprotection: RNA Deprotection-see bulletin. Technical Bulletin |
| Storage: Freezer storage, -10 to -30°C, dry |
| Stability in Solution: 2-3 days |
7-Deaza-Adenosine is lacking nitrogen at the 7-position, which is replaced bycarbon. The N7 position in adenosine takes part in non-Watson and Crick hydrogenbonding, which may be relevant to RNA folding and subsequent activity. ThisAdenosine analogue is also known as Tubercidin. 8-Aza-7-deaza-Adenosine is anisomer of Adenosine with virtually identical electron density. Again, the N7nitrogen is not available for hydrogen bonding. Nebularine or Purine Nucleosidecan be viewed as an Adenosine derivative that is lacking the exocyclic aminogroup. This molecule allows researchers to determine the relevance of theexocyclic amine of Adenosine to RNA structure and function. Ribozyme activity issubstantially affected by the substitution of modified pyrimidine bases.Zebularine (pyrimidin-2-one ribonucleoside) may be regarded as a Cytidinederivative lacking the exocyclic amino group. Zebularine and Pyridin-2-oneRibonucleoside, the 3-deaza analogue of Zebularine, are prime candidates for usein evaluating ribozyme activity and function. It should be noted that Zebularineis mildly fluorescent, absorbing at 298nm and emitting at 367nm. PseudoUridineis one of the most common modified nucleosides found in RNA. The availability ofa phosphoramidite will allow detailed research into the effects of this modifiedbase on RNA structure and activity.
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8-Aza-7-deaza-A-CE Phosphoramidite
8-Aza-7-deaza-A-CE Phosphoramidite
Glen Research
MSDS
Glen Report 19.1: Modified RNA Phosphoramidites Useful In Sirna Research And Biologically Significant 1-Methy-Adenosine
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8-Aza-7-deaza-A-CE Phosphoramidite
8-Aza-7-deaza-A-CE Phosphoramidite
Glen Research
DILUTION/COUPLING DATA
The table below shows pack size data and, for solutions, dilutions and approximate couplings based on normal priming procedures. Please link for more detailed usage information with the various synthesizers.
| ABI 392/394 | |||||||||
| Cat.No. | PackSize | Grams/Pack | 0.1M Dil.(mL) | LV40 | LV200 | 40nm | 0.2µm | 1µm | 10µm |
| Approximate Number of Additions | |||||||||
| 10-3083-95 | 50µmoles | .047grams | .5 | 3.33 | 2 | 1.25 | .91 | .67 | .17 |
| 10-3083-90 | 100µmoles | .094grams | 1 | 20 | 12 | 7.5 | 5.45 | 4 | 1 |
| 10-3083-02 | 0.25grams | .25grams | 2.66 | 75.33 | 45.2 | 28.25 | 20.55 | 15.07 | 3.77 |
| Expedite | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 50nm | 0.2µm | 1µm | 15µm | |
| Approximate Number of Additions | |||||||||
| 10-3083-95 | 50µmoles | .047grams | .75 | .07 | N/A | N/A | 1.79 | N/A | |
| 10-3083-90 | 100µmoles | .094grams | 1.5 | .07 | N/A | N/A | 4.92 | N/A | |
| 10-3083-02 | 0.25grams | .25grams | 3.97 | .07 | N/A | N/A | 15.21 | N/A | |
| Beckman | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 30nm | 200nm | 1000nm | ||
| Approximate Number of Additions | |||||||||
| 10-3083-95 | 50µmoles | .047grams | .75 | .07 | N/A | 1.65 | 1.55 | ||
| 10-3083-90 | 100µmoles | .094grams | 1.5 | .07 | N/A | 4.06 | 3.82 | ||
| 10-3083-02 | 0.25grams | .25grams | 3.97 | .07 | N/A | 12.03 | 11.3 | ||
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