Oligo Synthesis : CEPs
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5-OH-dC-CE Phosphoramidite
5-OH-dC-CE Phosphoramidite
Glen Research
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-1063-02 | 5-OH-dC-CE Phosphoramidite | 0.25g | £700.00£665.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-1063-90 | 5-OH-dC-CE Phosphoramidite | 100µmoles | £260.00£247.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
Related products
5-OH-dC-CE Phosphoramidite
5-OH-dC-CE Phosphoramidite
Glen Research
| 5-OH-dC-CE Phosphoramidite |
Catalog Number: 10-1063-xx
Description: 5-OH-dC-CE Phosphoramidite
| 5"-Dimethoxytrityl-N-benzoyl-O5-Benzoyl-2"-deoxyCytidine,3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite | ||
| Formula: C53H56N5O10P | M.W.: 954.03 | F.W.: 305.18 |
Diluent: Anhydrous Acetonitrile |
| Coupling: No changes needed from standard method recommended by synthesizer manufacturer. |
| Deprotection: Mild deprotection: Ammonium Hydroxidefor 24hours at room temperature. |
| Storage: Refrigerated storage, maximum of 2-8°C, dry |
| Stability in Solution: 2-3 days |
DNA Damage/Repair
Cellular DNA is constantly being damaged by oxidation andalkylation, by free radicals, and by ultraviolet and ionizing radiation. Thebody has therefore evolved a number of repair enzyme systems to excise andrepair these lesions. The 8-oxo purine monomers allow investigation of thestructure and activity of oligonucleotides containing an 8-oxo mutation which isformed naturally when DNA is subjected to oxidative conditions or ionizingradiation. 5,6-Dihydro pyrimidines are naturally occurring compounds that arestructural components of alanine transfer RNA. Dihydrouracil and the hydroxypyrimidines are major base damage products formed by exposure of DNA to ionizingradiation.
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5-OH-dC-CE Phosphoramidite
5-OH-dC-CE Phosphoramidite
Glen Research
Literature Highlights
MSDS
| Glen Report 11.1: MORE NOVEL MONOMERS |
| Glen Report 13.1: C-5 PROPYNES, CYTOFECTIN AND OTHER PRODUCT UPDATES |
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
5-OH-dC-CE Phosphoramidite
5-OH-dC-CE Phosphoramidite
Glen Research
EXTINCTION DATA
| Item | Nucleoside | λMax-1 | Emax-1 | λMax-2 | Emax-2 | E260 |
| (nm) | (ml/µmole) | nm | (ml/µmole) | (ml/µmole) | ||
| 10-1063 | 5-OH-dC | 292 | 3.4 | 220 | 13.3 | 6.3 |
DILUTION/COUPLING DATA
The table below shows pack size data and, for solutions, dilutions and approximate couplings based on normal priming procedures.
| ABI 392/394 | |||||||||
| Cat.No. | PackSize | Grams/Pack | 0.1M Dil.(mL) | LV40 | LV200 | 40nm | 0.2µm | 1µm | 10µm |
| Approximate Number of Additions | |||||||||
| 10-1063-02 | 0.25grams | .25grams | 2.62 | 74 | 44.4 | 27.75 | 20.18 | 14.8 | 3.7 |
| 10-1063-90 | 100µmoles | .095grams | 1 | 20 | 12 | 7.5 | 5.45 | 4 | 1 |
| Expedite | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 50nm | 0.2µm | 1µm | 15µm | |
| Approximate Number of Additions | |||||||||
| 10-1063-02 | 0.25grams | .25grams | 3.91 | .07 | 71.8 | 44.88 | 32.64 | 4.49 | |
| 10-1063-90 | 100µmoles | .095grams | 1.5 | .07 | 23.6 | 14.75 | 10.73 | 1.48 | |
| Beckman | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 30nm | 200nm | 1000nm | ||
| Approximate Number of Additions | |||||||||
| 10-1063-02 | 0.25grams | .25grams | 3.91 | .07 | 73.4 | 45.88 | 33.36 | ||
| 10-1063-90 | 100µmoles | .095grams | 1.5 | .07 | 25.2 | 15.75 | 11.45 | ||
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