Oligo Synthesis : CEPs
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5"-Amino-Modifier TEG PDA
5"-Amino-Modifier TEG PDA
Glen Research
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-1949-02 | 5"-Amino-Modifier TEG PDA | 0.25g | £336.00£319.20Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-1949-90 | 5"-Amino-Modifier TEG PDA | 100 µmole | £84.00£79.80Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
Related products
5"-Amino-Modifier TEG PDA
5"-Amino-Modifier TEG PDA
Glen Research
5"-Amino-Modifier TEG PDA
Catalog Number: 10-1949-xx
Description: 5"-Amino-Modifier TEG PDA
| 10-(N2-methylphthalimidyl-N1-ethyl)-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite | ||
| Formula: C26H43N4O7P | M.W.: 554.62 | F.W.: 255.21 |
Diluent: Anhydrous Acetonitrile |
| Coupling: No changes needed from standard method recommended by synthesizer manufacturer. |
| Deprotection: Synthesize using acetyl-protected dC (10-1015-xx) and deprotect in 30% Ammonium Hydroxide/40% Methylamine 1:1 (AMA) at 65°C for 10 minutes. |
| Storage: Freezer storage, -10 to -30°C, dry |
| Stability in Solution: 1-2 days |
Our more recent 5’-amino modifiers, protected by a novel phthalic acid diamide (PDA) protecting group, are stable solids . In contrast to the TFA protected amino modifiers, which are viscous oils, the analogous PDA protected compounds are granular powders. This important property of these compounds allows straightforward handling, storage and aliquoting and leads to a significant increase in stability.
Deprotection with methylamine in gas phase or aqueous solution or AMA leads to fast and complete removal of the PDA protecting group. However, ammonium hydroxide will not drive the equilibrium reaction to completion and only partial deprotection occurs - overnight deprotection with ammonium hydroxide will yield around 80% active amine.
We are offering three PDA Amino-Modifiers:
5’-Amino-Modifier C6-PDA
Hydrophobic 5’-Amino-Modifier C12-PDA
Hydrophilic 5’-Amino-Modifier-TEG-PDA
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
5"-Amino-Modifier TEG PDA
5"-Amino-Modifier TEG PDA
Glen Research
Material Safety Data Sheet
Glen Report 24.1: New Products - Solid, Stable amino-Modifiers - PDA amino-Modifiers
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
5"-Amino-Modifier TEG PDA
5"-Amino-Modifier TEG PDA
Glen Research
DILUTION/COUPLING DATA
The table below shows pack size data and, for solutions, dilutions and approximate couplings based on normal priming procedures. Please link formore detailed usage informationwith the various synthesizers.
| ABI 392/394 | |||||||||
| Cat.No. | PackSize | Grams/Pack | 0.1M Dil.(mL) | LV40 | LV200 | 40nm | 0.2µm | 1µm | 10µm |
| Approximate Number of Additions | |||||||||
| 10-1949-90 | 100µmoles | .055grams | 1 | 20 | 12 | 7.5 | 5.45 | 4 | 1 |
| 10-1949-02 | 0.25grams | .25grams | 4.51 | 137 | 82.2 | 51.38 | 37.36 | 27.4 | 6.85 |
| Expedite | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 50nm | 0.2µm | 1µm | 15µm | |
| Approximate Number of Additions | |||||||||
| 10-1949-90 | 100µmoles | .055grams | 1.5 | .07 | 23.6 | 14.75 | 10.73 | 1.48 | |
| 10-1949-02 | 0.25grams | .25grams | 6.73 | .07 | 128.2 | 80.13 | 58.27 | 8.01 | |
| Beckman | |||||||||
| Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 30nm | 200nm | 1000nm | ||
| Approximate Number of Additions | |||||||||
| 10-1949-90 | 100µmoles | .055grams | 1.5 | .07 | 25.2 | 15.75 | 11.45 | ||
| 10-1949-02 | 0.25grams | .25grams | 6.73 | .07 | 129.8 | 81.13 | 59 | ||
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
