

Oligo Synthesis : CEPs
Prices quoted are for single packs only. For multiples of the same product please request a quote. Some of Glen"sproductsarehazardousandmay be subject to additional shipping charges. Full product information is available onGlen Research"s website.
Tocopherol-TEG Phosphoramidite
Tocopherol-TEG Phosphoramidite
Glen Research
Catalogue No. | Description | Pack Size | Price | Qty |
|
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10-1977-02 | Tocopherol-TEG Phosphoramidite | 0.25g | £460.00£437.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
10-1977-90 | Tocopherol-TEG Phosphoramidite | 100µmoles | £240.00£228.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
10-1977-95 | Tocopherol-TEG Phosphoramidite | 50µmoles | £128.00£121.60Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
Tocopherol-TEG Phosphoramidite
Tocopherol-TEG Phosphoramidite
Glen Research
Tocopherol-TEG Phosphoramidite |
Catalog Number: 10-1977-xx
Description: α-Tocopherol-TEG Phosphoramidite
1-Dimethoxytrityloxy-3-O-[(9-DL-α-tocopheryl)-triethyleneglycol-1-yl]-glyceryl-2-O-[(2-cyanoethyl)-(N,N,-diisopropyl)]-phosphoramidite | ||
Formula: C68H103N2O10P | M.W.: 1139.56 | F.W.: 698.91 |
Diluent: Anhydrous AcetonitrileAdd fresh diluent to product vial to recommended concentration and swirl vial occasionally over several minutes until product is completely dissolved. (Some oils may require between 5 and 10 minutes.) Use care to maintain anhydrous conditions. In case of transfer to alternate vial type, ensure recipient vial has been pre-dried. For more information, see http://www.glenres.com/Technical/TB_ABITransfer.pdf. |
Coupling: 15 minute coupling time. DCI activator (30-3150-xx) is recommended. To maintain label yield, carry out the synthesis DMT-ON. |
Deprotection: To maintain label yield as a 5" modifier, treat column with 10% diethylamine in acetonitrile for 2 minutes at room temperature (2x) to remove cyanoethyl protecting groups. Rinse column with ACN and then cleave and deprotect as required by nucleobases. |
Storage: Freezer storage, -10 to -30°C, dry |
Stability in Solution: 1-2 days |
TOCOPHEROL LABELLING
Vitamin E is both lipophilic and non-toxic even at high doses so would be an excellent candidate as a lipophilic carrier for oligonucleotides. Therefore, as an addition to our cholesteryl product line, we offer simple a-tocopheryl (vitamin E) labelling. Totally synthetic a-tocopherol is racemic at its three chiral centers and is used to prepare this product.
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
Tocopherol-TEG Phosphoramidite
Tocopherol-TEG Phosphoramidite
Glen Research
Material Safety Data Sheet
Glen Report 22.1: New Products - a-Tocopherol-TEG Phosphoramidite and 3"-Thiol-Modifier 6 S-S CPG |
Glen Report 24.1: New Product - 5"-Stearyl Phosphoramidite - An Alternative Lipophilic Carrier |
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
Tocopherol-TEG Phosphoramidite
Tocopherol-TEG Phosphoramidite
Glen Research
DILUTION/COUPLING DATA
The table below shows pack size data and, for solutions, dilutions and approximate couplings based on normal priming procedures. Please link formore detailed usage informationwith the various synthesizers.
ABI 392/394 | |||||||||
Cat.No. | PackSize | Grams/Pack | 0.1M Dil.(mL) | LV40 | LV200 | 40nm | 0.2µm | 1µm | 10µm |
Approximate Number of Additions | |||||||||
10-1977-95 | 50µmoles | .057grams | .5 | 3.33 | 2 | 1.25 | .91 | .67 | .17 |
10-1977-90 | 100µmoles | .114grams | 1 | 20 | 12 | 7.5 | 5.45 | 4 | 1 |
10-1977-02 | 0.25grams | .25grams | 2.19 | 59.67 | 35.8 | 22.38 | 16.27 | 11.93 | 2.98 |
Expedite | |||||||||
Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 50nm | 0.2µm | 1µm | 15µm | |
Approximate Number of Additions | |||||||||
10-1977-95 | 50µmoles | .057grams | .75 | .07 | 8.6 | 5.38 | 3.91 | .54 | |
10-1977-90 | 100µmoles | .114grams | 1.5 | .07 | 23.6 | 14.75 | 10.73 | 1.48 | |
10-1977-02 | 0.25grams | .25grams | 3.27 | .07 | 59 | 36.88 | 26.82 | 3.69 | |
Beckman | |||||||||
Cat.No. | PackSize | Grams/Pack | Dilution(mL) | Molarity | 30nm | 200nm | 1000nm | ||
Approximate Number of Additions | |||||||||
10-1977-95 | 50µmoles | .057grams | .75 | .07 | 10.2 | 6.38 | 4.64 | ||
10-1977-90 | 100µmoles | .114grams | 1.5 | .07 | 25.2 | 15.75 | 11.45 | ||
10-1977-02 | 0.25grams | .25grams | 3.27 | .07 | 60.6 | 37.88 | 27.55 |
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200