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商品详细Athens Research/Cambio - Excellence in Molecular Biology/100 umole/10-1555-90
Athens Research/Cambio - Excellence in Molecular Biology/100 umole/10-1555-90
Athens Research/Cambio - Excellence in Molecular Biology/100 umole/10-1555-90
商品编号: 10-1555-90
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产地: 美国(厂家直采)
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产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍
Oligo Synthesis

Oligo Synthesis : CEPs

Prices quoted are for single packs only. For multiples of the same product please request a quote. Some of Glen"sproductsarehazardousandmay be subject to additional shipping charges. Full product information is available onGlen Research"s website.

  • Catalogue
  • Description
  • Protocols
  • References

TIPS-5-Ethynyl-dU-CE Phosphoramidite

TIPS-5-Ethynyl-dU-CE Phosphoramidite5"-Dimethoxytrityl-5-triisopropylsilyl-ethynyl-2"-deoxyUridine, 3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
  • Change to:
  • €
10-1555-02TIPS-5-Ethynyl-dU-CE Phosphoramidite0.25 g£780.00£741.00Offer until : 31-Mar-2021Offer Code : GLEN55% off all Glen productsView OfferQuantityAdd to Order
10-1555-90TIPS-5-Ethynyl-dU-CE Phosphoramidite100 umole£296.00£281.20Offer until : 31-Mar-2021Offer Code : GLEN55% off all Glen productsView OfferQuantityAdd to Order
10-1555-95TIPS-5-Ethynyl-dU-CE Phosphoramidite50 umole£156.00£148.20Offer until : 31-Mar-2021Offer Code : GLEN55% off all Glen productsView OfferQuantityAdd to Order

TIPS-5-Ethynyl-dU-CE Phosphoramidite

TIPS-5-Ethynyl-dU-CE Phosphoramidite5"-Dimethoxytrityl-5-triisopropylsilyl-ethynyl-2"-deoxyUridine, 3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

5-Ethynyl-dU offers convenient click conjugation with an azide to generate a label rigidly attached to one of the oligonucleotide bases. 5-Ethynyl-dU is subject to base-catalyzed hydration during cleavage and deprotection, especially when using a strong base or heat. Hydration of an ethynyl group forms a methyl ketone which subsequently blocks potential click reactions. Mild deprotection conditions are necessary when using 5-Ethynyl-dU-CE Phosphoramidite to prevent this side reaction. TIPS-5-Ethynyl-dU-CE Phosphoramidite, containing a protected alkyne, offers broader compatibility with oligonucleotide synthesis and deprotection. Protecting the 5-ethynyl group with a triisopropylsilyl (TIPS) protecting group prevents acid or base catalyzed hydration during oligonucleotide synthesis and workup. A quick treatment with TBAF removes the TIPS protecting group.

M.W.: 911.15
F.W.: 314.19

Diluent: Anhydrous Acetonitrile

Coupling: 3 minute coupling time recommended

Deprotection: No changes needed from standard method recommended by synthesizer manufacturer. TIPS removal: After deprotection, dry down oligo and take up in 0.5 mL DMF. Add 0.1 mL TBAF. Vortex and keep at 45°C for 15 minutes. Quench with 0.5 mL 2 M TEAA and desalt on Glen Gel-Pak™ column or equivalent.

Storage: Storage: Refrigerated storage, maximum of 2-8°C, dry

Stability in Solution: 1-2 Days

Please Note: All products of baseclick are patent protected and available in collaboration with baseclick. Baseclick GmbH has filed the following patent applications: 1. WO2006/117161, New labelling strategies for the sensitive detection of analytes. 2. WO2008/952775, Click Chemistry for the production of reporter molecules. Baseclick GmbH holds a worldwide license for the research market of the "Click Chemistry" patent from "The Scripps Research Institute": 3. WO03/101972, Copper-catalysed ligation of azides and acetylenes.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

TIPS-5-Ethynyl-dU-CE Phosphoramidite

TIPS-5-Ethynyl-dU-CE Phosphoramidite5"-Dimethoxytrityl-5-triisopropylsilyl-ethynyl-2"-deoxyUridine, 3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

MSDS

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

TIPS-5-Ethynyl-dU-CE Phosphoramidite

TIPS-5-Ethynyl-dU-CE Phosphoramidite5"-Dimethoxytrityl-5-triisopropylsilyl-ethynyl-2"-deoxyUridine, 3"-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

Glen Report 28.2: New Product - TIPS-5-Ethynyl-dU-CE Phosphoramidite

  • C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064; V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.
  • C. J. Burrows, J. G. Muller, Chem. Rev. 1998, 98, 1109 – 1151.
  • T. R. Chan, R. Hilgraf, K. B. Sharpless, V. V. Fokin, Org. Lett. 2004, 6, 2853 – 2855.
  • J. Gierlich, G. A. Burley, P. M. E. Gramlich, D. M. Hammond, T. Carell, Org. Lett. 2006, 8, 3639-3642. F. Seela, V. R. Sirivolu, Chem. Biodiversity 2006, 3, 509-514.
  • P. M. E. Gramlich, S. Warncke, J. Gierlich, T. Carell, Angew. Chem. 2008, 120, 3491–3493; Angew. Chem. Int. Ed. 2008, 47, 3442– 3444.
  • P. M. E. Gramlich, C. T. Wirges, A. Manetto, T. Carell, Angew. Chem. Int. Ed. 2008, 47, 8350-8358.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

品牌介绍
Athens Research & Technology—供应多款蛋白、酶制品 Athens Research & Technology是成立于2010年的新兴生物高科技制品公司,该公司拥有BSL-2实验室及超过11000平方英尺的cGMP生产厂房,并且通过ISO 9001:2008认证。Athens公司致力于纯化分离高纯度,高活性的人类蛋白质及研发多克隆抗血清产品。提供包括高纯度及活性的丝氨酸蛋白酶,蛋白酶抑制剂,中性粒细胞酶,载脂蛋白,脂蛋白,血小板蛋白,转铁蛋白,免疫球蛋白等等。公司产品适用于炎症,冠状动脉疾病,自身免疫性疾病,癌症,阿尔茨海默氏病等众多研究领域,已被世界*制药公司及诊断试剂公司用于体外诊断试剂盒/免疫检测试剂盒、药物筛选、细胞培养液(包括干细胞)等产品研发。除了人类蛋白质,我们还从动物血清和组织中分离多种蛋白质及酶类。此外,Athens Research and Technology还提供特殊试剂/蛋白定制服务,以满足研究人员的不同需求。