MW:138,000
ExtinctionCoefficient:1.03
FrozeninPBS,pH7.4
Storage:-70°C-AvoidFreeze/Thawcycles
BuyPurifiedComplementC3cfromHumanPlasma.
BulkQtyAvailable.
ComplementC3(C3)isthemostabundantcomponentofthecomplementsystem,withlevelsinhumanplasmaof~1.2-1.5mg/ml.Itiscentraltotheactivationofboththeclassicalandalternativecomplementpathways,bothofwhichleadtotheproteolyticprocessingofC3toC3aandC3b.C3existsasaheterodimerwithmolecularmassesof115kDaand75kDa,althoughitisreADIlyprocessedtocreateC3a,C3borC3cdependingontheprocessedstate.AthensResearchandTechnologycurrentlyonlysellstheC3cform.
References:TackBFandJWPrahl.1976.Biochemistry.15:4513,TackBFetal.1981.MethodsEnzymol.80:64,Janatova,J.1988.MethodsEnzymol.162:579.
Purity:>=95%bySDS-PAGE.
ReactstoC3antiseraonWesternBlot
NegativeagainstC4antiseraonWesternBlot
NotBIOLOGicallyactive.
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.