MW:55,000-65,000Da
ExtinctionCoefficient:0.92
Lyophilizedfrom30mMsodiumphosphate,pH6.8
Storage:-20°C
BuyPurifiedNativeAngiotensinogenfromHumanPlasmadirectfromthemanufacturer.
Price$110.00/1x100ug.BulkQtyAvailable.
Angiotensinogen(AGT)isaglycoproteinfoundinplasmaataconcentrationof2.8-7.1mgper100mLinhealthyindividuals.AGTisproducedprimarilybytheliverbutalsoissynthesizedinthebrain,largearteries,kidneysandADIposetissue.Inplasmaitexistsasamonomericform(55-65kDa)aswellasahighmolecularmassform(200-550kDa).Innon-pregnantindividualswithnormalbloodpressure,thehighmolecularmassformaccountsfor3%oftotalcirculatingAGT.InthefirsthalfofpregnancythetotalAGTincreasesby4-foldandthehighmolecularmassformincreasesby20-fold.Upto80%ofthetotalAGTinamnioticfluidisthehighmolecularmassform.
Angiotensinogenisanessentialcomponentoftherenin-angiotensinsystem,apotentregulatorofbloodpressure,bodyfluidandelectrolytehomeostasis.ItfunctionsasthesubstrateforhumanreninandistheprecursormoleculeforAngiotensins1,2,3,4,1-9,1-7,1-5and1-4.AGTisalsoamemberoftheSERPINfamilybutitisnotknowntopossessprotease-inhibitoryactivity.Levelsinplasmaareincreasedbyplasmacorticosteroid,estrogen,thyroidhormoneandangiotensin-2levels.
Purity:>=95%bySDS-PAGE
Synonym:Hypertensinogen,Reninsubstrate
Preparedfromplasmashowntobenon-reactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDA-requiredtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.