MW:56,000
ExtinctionCoefficient:0.63
Lyophilizedfrom20mMNaphosphate,pH7.4,with150mMNaCl.
Storage:-20°C
BuyPurifiedNativeHumanGCGlobulin/VitaminDBindingProtein
Price$60.00/mg.BulkQtyAvailable.
Analpha2glycoproteincomposedofasinglepolypeptidechainandpresentinplasmaatlevelsof20-55mg/100ml.ItfunctionsinthebindingandtransportofvitaminDandmayalsoplayanimportantroleinactinhomeostatissinceithasbeenshowntobindmonomericactinwithhighaffinity.GC-globulinalsobindsmembranesofbothcirculatingBandTlymphocytes.Clinically,concentrationsarereducedinpatientswithsevereliverdiseases.GC-globulinmayalsoplayanimportantroleinthemechanismoftheosteomalaciathatoccurswithItai-Itaidisease.
Ref:
Lee,W.M.etal.1987.Hepatology,7,825.
Teranishi,H.etal.1983.Toxicol.Lett.15,7.
Purity:>=95%bySDS-PAGE
ProductCitation:
Trujillo,Glenda,DavidM.HABIel,LingyinGe,MahalakshmiRamadass,NancyE.Cooke,andRichardR.Kew."NeutrophilRecruitmenttotheLunginBothC5a-andCXCL1-InducedAlveolitisIsImpairedinVitaminD–BindingProtein-DeficientMice." TheJournalofImmunology (2013).
Ge,Lingyin,GlendaTrujillo,EdmundJ.Miller,andRichardR.Kew."CirculatingComplexesoftheVitaminDBindingProteinwithG-ActinInduceLungInflammationbyTargetingEndothelialCells." ImmunoBIOLOGy (2013).
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.