MW:~570,000Da(wholemolecule)
~70,000-75,000Da(alphachains)
~40,000-45,000Da(betachain)
ExtinctionCoefficient:1.4
Lyophilizedfrom10mMTrispH7.4,100mMNaCl,0.05%NaN3
FreeofProteinS
Storage:-20°C
BuyPurifiedC4bBindingProtein,FreeofProteinS,HumanPlasma,$315.00/mg.
BulkQtyAvailable.
C4b-bindingproteinisaregulatoryproteinoftheComplementCascadethatpossessesdecay-acceleratingactivity.Circulatinginplasma,itaidsinthecontroloffluid-phaseandsurface-associatedactivationofC3andC5andservesasacofactortoFactor1intheproteolyticdegradationofC4b.
Therearethreeisoformscirculatinginplasma;7alphachainsand1Betachain,6alphachainsand1Betachain,and7alphachainswithoutaBetachain.The7alpha,1Betaformisthemostabundant.AllC4BPmoleculesthatcontainaBetachaincirculateinplasmainahigh-affinity,calcium-dependentcomplexwithvitaminK-dependent,anticoagulantProteinS.
C4b-bindingproteinhasbeeninvestigatedforitsroleinAlzheimer"sDisease,Psoriasis,aswellasautoimmunediseasesincludingRheumatoidArthritis,anddifferenttypesofCancer.
Purity:>=95%bySDS-PAGE.
ProductCitation:
Sanderson-Smith,Martina,DavidMPDeOliveira,JulienGuglielmini,DavidJ.McMillan,ThereseVu,JessicaK.Holien,AnnaHenninghametal."AsystematicandfunctionalclassificationofStreptococcuspyogenesthatservesasanewtoolformoleculartypingandvaccinedevelopment."JournalofInfectiousDiseases (2014):jiu260.
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.
