MW:Hp1-1:86,000;Hp2-1:200,000;Hp2-2:400,000
ExtinctionCoefficient:1.20
Salt-freelyophilizedsolid.
Storage:-20°C
BuyPurifiedNativeHumanHaptoglobin,HumanPlasma.
Price$75.00/mg.BulkQtyAvailable.
Anacute-phaseplasmaproteinfoundinhumanplasmaat100-300mgper100ml.Bindshemoglobin,thuspreventinglossofironthroughthekidneys.Humansarepolymorphicforhaptoglobin,withthreemajorphenotypes:Hp1-1,Hp2-1,andHp2-2.Whilethephenotypicdistributioncanvarygreatlybetweenethnicitiesandgeographiclocation,theHp2-1phenotypeisthemostprevalentphenotypeinhumans.PlasmaconcentrationsofhaptoglobinarehighestinindividualswithHp1-1,intermediateinHp2-1individuals,andlowestinHp2-2individuals.Hp1-1isthemosteffectiveatbindinghemoglobin,andHp2-2istheleasteffective.Thisfunctionaldifferencemaybeassociatedwiththefrequencyandseverityofepilepsyattacks,asresearchershavefoundacorrelationbetweenrecurringseizuresandtheHp2-2phenotype.
Ref:
Smithies,Oetal.1955.Biochem.J.61,629.
Sadrzadeh,S.M.H.etal.2004.Clin.Chem.50,1095.
Purity:>=95%bySDS-PAGE;bypolymorphicform PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests. AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.
EndotoxinLevel:<2.0 EU/mg by fluorogenic assay, Lonza,50-658U