MW:23,500
ExtinctionCoefficient:0.664
Salt-freelyophilizedsolid.
Storage:-20°C
BuyPurifiedNativeHumanCathepsinG(CatG),HumanNeutrophil.
Price$165.00/100ug.BulkQtyAvailable.
ThisenzymedegradescollagenandproteoglycanandcanalsocausethereleaseofangiotensinIIfromangiotensinIorangiotensinogen.Ithasbeenimplicatedinconnectivetissuediseasessuchasemphysemaandrheumatoidarthritis.
Ref:Travis,J.etal.1978.Biochemistry.17,5651.
Activity:2-4unitspermgprotein.OneunitisdefinedastheamountofenzymethathydrolyzesoneumoleofSuc-Ala-AlaPro-Phe-pNA(1mM)perminuteat25oCin160mMTris-HCl,pH7.4,with1.6MNaCl.
Purity:>=95%bySDS-PAGE
ProductCitations:
Mittendorf,ElizabethA.,GheathAlatrash,NaQiao,YunWu,PariyaSukhumalchandra,LisaS.StJohn,AnneV.Philipsetal."Breastcancercelluptakeoftheinflammatorymediatorneutrophilelastasetriggersananticanceradaptiveimmuneresponse." Cancerresearch 72,no.13(2012):3153-3162.
Baumann,Mathias,ChristineTNPham,andCharafBenarafa."SerpinB1iscriticalforneutrophilsurvivalthroughcell-autonomousinhibitionofcathepsinG." Blood 121,no.19(2013):3900-3907
vandenBerg,CarmenW.,etal."MechanismofNeutrophilDysfunction:NeutrophilSerineProteasesCleaveandInactivatetheC5aReceptor." TheJournalofImmunology 192.4(2014):1787-1795.
PreparedfromwholebloodshowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.