MW:27,500
ExtinctionCoefficient:2.0

Frozenin50mMNaAcetate,pH5.0,with1mMEDTA

Storage:-70°Corlower

BuyPurifiedNativeHumanCathepsinB(CatB),HumanLiver.
Price$140.00/25ug.BulkQtyAvailable.

CathepsinB,acysteineproteinase,islocatedinlysosomesandisinvolvedintissuedegradationandrestructuring.Specifically,cathepsinBisbelievedtobeinvolvedintheintracellulardigestionofextracellularproteinstakenupbyendocytosis.

Ref:RichD.H.,BrownM.A.andBarrettA.J.1986BiochemJ,235,731-734.

Activity:Greaterthan200unitspermgprotein.OneunitisdefinedastheamountofenzymethathydrolyzesoneumoleofZ-Arg-Arg-beta-naphthylamideperminuteat40oC,using100mMNa/Kphosphate,pH6.0,with1.33mMEDTAand2mMDTTastheactivationbuffer.

Purity:>=95%bySDS-PAGE

ProductCitations:
Armstrong,Andrea,NiklasMattsson,HannaAppelqvist,CamillaJanefjord,LinneaSandin,LottaAgholme,BobOlssonetal."LysosomalNetworkProteinsasPotentialNovelCSFBioMarkersforAlzheimer’sDisease."Neuromolecularmedicine 16,no.1(2014):150-160.
Watson,Andre,CaraYocum,VaibhavPandit,andShivaP.Kotha."OptimizingPolymericNanoparticleCoreDesignsforGeneDelivery."In BioengineeringConference(NEBEC),201339thAnnualNortheast,pp.1-2.IEEE,2013.
Toneff,Thomas,LydianeFunkelstein,CharlesMosier,ArmenAbagyan,MichaelZiegler,andVivianHook."Beta-AmyloidPeptidesUndergoRegulatedCo-SecretionwithNeuropeptideandCatecholamineNeurotransmitters."Peptides (2013).
Elie,BenelitaTina,VasilenaGocheva,TanayaShree,StacieA.Dalrymple,LeslieJ.Holsinger,andJohannaA.Joyce."Identificationandpre-clinicaltestingofareversIBLecathepsinproteaseinhibitorrevealsanti-tumorefficacyinapancreaticcancermodel." Biochimie 92,no.11(2010):1618-1624.

PreparedfromtissueshowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.