MW:725,000
ExtinctionCoefficient:0.81
Lyophilizedfrom100mMNaPhosphate,pH7.3,
Storage:-20°C
BuyPurifiedNativeHumanAlpha2Macroglobulin,HumanPlasma,FastForm
Price$80.00/1mg.BulkQtyAvailable.
Alpha2Macroglobulin(A2M)isaplasmaproteaseinhibitorwhichhasbeenshowntoexistintwoforms.TheSlowFormofA2M(S-A2M)istheformwhichpossessestheABIlitytobindandinhibitproteasesbya“trap”method.TheFastFormofA2M(F-A2M)isgeneratedwhenS-A2MundergoesaconformationalchangeduetoeitherentrapmentofaproteaseintheA2Mbaitregion,orchemicalcleaveageofaninternalthiolesterbondlocatednearthebaitregion.F-A2Mdoesnotpossesstheabilitytobindandinhibitproteaseactivity.F-A2Misrapidlytakenupbytheliver,withahalflifeof2-4minutes.
Invivo,F-A2Mtypicallyrepresentsonly0.17–0.7%ofthetotalA2Minbloodplasmaofadults.TheF-A2Mplasmaconcentrationis,however,increasedinmanydiseasestatesincludingpancreatitis,multiplesclerosisandsepsis.F-A2MhasalsobeenimplicatedintheinhibitionofamyloidformationassociatedwithAlzheimer’sdiseaseandspongiformencephalopathies.
Purity:>=95%bySDS-PAGE
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.