Oligo Synthesis : CEPs
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5-Me-C-2"-MOE-Phosphoramidite
5-Me-C-2"-MOE-Phosphoramidite
Glen Research
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-3211-05 | 5-Me-C-2"-MOE-Phosphoramidite | 0.5g | £30.00£28.50Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3211-10 | 5-Me-C-2"-MOE-Phosphoramidite | 1.0g | £60.00£57.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3211-20 | 5-Me-C-2"-MOE-Phosphoramidite | 2.0g | £120.00£114.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-3211-SP | 5-Me-C-2"-MOE-Phosphoramidite | 1.0g | £60.00£57.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
Related products
5-Me-C-2"-MOE-Phosphoramidite
5-Me-C-2"-MOE-Phosphoramidite
Glen Research
5-Me-C-2"-MOE-Phosphoramidite
5"-O-(4,4"-Dimethoxytrityl)-2"-O-methoxyethyl-5-methyl-N4-benzoyl- cytidine-3"-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Description
Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. The
se drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.
Details
Usage
- Coupling: 6 minute coupling time recommended
- Deprotection: No changes needed from standard method recommended by synthesizer manufacturer. Note: Deprotection in AMA (50:50 Ammonium hydroxide/MethylAmine) may result in a 4-5% 5-methyl-N4-methyl-C side product at the modification site.
| Specifications | |
|---|---|
| Diluent | Anhydrous Acetonitrile |
| Storage | Refrigerated storage, maximum of 2-8°C, dry |
| Stability | 1-2 Days |
Technical Documents
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